overview of the biology of type i interferons生物学的i型干扰素的概述.pdfVIP

Kalliolias and Ivashkiv Arthritis Research Therapy 2010, 12(Suppl 1):S1 /content/12/S1/S1 R E V I E W Overview of the biology of type I interferons 1 1,2 George D Kalliolias and Lionel B Ivashkiv * arma men tarium and are indicated for several disease Abstract entities [2,8]. Firstly, type I interferons are widely used for Type I interferons are pleiotropic cytokines with the treatment of chronic viral infections, mainly by antiviral, antitumor and immunoregulatory functions. hepatitis B virus and hepatitis C virus [2]. Several major An aspect of their complex biology is the paradox break throughs in the fi eld of interferon research have that, depending on context, type I interferons can established the notion that type I interferons are not only be anti-inl ammatory and tissue protective or can antiviral peptides but pleiotropic cytokines. Along these be proinl ammatory and promote autoimmunity. lines it was observed that type I interferons can inhibit Along these lines, the activation of type I interferon growth of some tumors by suppressing prolifera tion and pathways is ef ective in suppressing disease activity in inducing cell apoptosis, inhibiting angiogenesis, increas- patients with multiple sclerosis and in animal models ing immunogenicity of tumor cells and activating cyto- of arthritis and colitis, while there is an expectation toxicity against tumor cells [2].