parasite-host interaction in malaria genetic clues and copy number variationparasite-host交互在疟疾的基因线索和拷贝数变异.pdf

Review Parasite-host interaction in malaria: genetic clues and copy number variation Imad Faik, Elisandra Grangeiro de Carvalho and Jürgen FJ Kun Address: Institute for Tropical Medicine, University Tübingen, Wilhelmstr. 27, 72074 Tübingen, Germany. Correspondence: Jürgen FJ Kun. Email: juergen.kun@uni-tuebingen.de health issues, especially in developing countries. In the Abstract year 2001, about 14.5 million deaths were attributed to the In humans, infections contribute highly to mortality and morbidity rates worldwide. Malaria tropica is one of the major infectious effects of infectious diseases. About 40% of the world diseases globally and is caused by the protozoan parasite population is at risk for malaria, causing around 1 million Plasmodium falciparum. Plasmodia have accompanied human deaths each year, predominantly in infants [2]. beings since the emergence of humankind. Due to its patho- genicity, malaria is a powerful selective force on the human Malaria is a devastating disease that not only has an effect genome. Genetic epidemiology approaches such as family and on the health system, but also slows the rate of long-term twin studies, candidate gene studies, and disease-association studies have identified a number of genes that mediate relative economic growth and development. Global climate change protection against the severest forms of the disease. New and a possible further migration of parasites will put even molecular approaches, including genome-wide association more people at risk in the future.