peak and averaged bicoherence for different eeg patterns during general anaesthesia峰值和平均后全身麻醉期间不同的脑电波模式.pdfVIP

Pritchett et al. BioMedical Engineering OnLine 2010, 9:76 /content/9/1/76 RESEARCH Open Access Peak and averaged bicoherence for different EEG patterns during general anaesthesia 1,2* 2 2 3,4 1 2 Stacey Pritchett , Eugene Zilberg , Zheng Ming Xu , Paul Myles , Ian Brown , David Burton * Correspondence: stacey. Abstract pritchett@ 1Electrical and Computer Science Background: Changes in nonlinear neuronal mechanisms of EEG generation in the Engineering, Monash University, Clayton, Vic, Australia course of general anaesthesia have been extensively investigated in research literature. A number of EEG signal properties capable of tracking these changes have been reported and employed in anaesthetic depth monitors. The degree of phase coupling between different spectral components is a marker of nonlinear EEG generators and is claimed to be an important aspect of BIS. While bicoherence is the most direct measure of phase coupling, according to published research it is not directly used in the calculation of BIS, and only limited studies of its association with anaesthetic depth and level of consciousness have been published. This paper investigates bicoherence parameters across equal band and unequal band bifrequency regions, during different states of anaesthetic depth relating to routine clinical anaesthesia, as det