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peptide vaccine therapy in colorectal cancer肽疫苗治疗结直肠癌.pdf

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peptide vaccine therapy in colorectal cancer肽疫苗治疗结直肠癌

Vaccines 2013, 1, 1-16; doi:10.3390/vaccines1010001 OPEN ACCESS vaccines ISSN 2076-393X /journal/vaccines Review Peptide Vaccine Therapy in Colorectal Cancer Aleksandra Bartnik, Ajit Johnson Nirmal and Shi-Yu Yang * Research Department of General Surgery, Division of Surgery and Interventional Science, UCL Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK; E-Mails: o.bartnik@ucl.ac.uk (A.B.); ajit.nirmal.10@alumni.ucl.ac.uk (A.J.N.) * Author to whom correspondence should be addressed; E-Mail: shiyu.yang@ucl.ac.uk; Tel.: +44-20-7594-0500; Fax: +44-20-7462-6224. Received: 6 July 2012; in revised form: 15 August 2012 / Accepted: 16 August 2012 / Published: 24 August 2012 Abstract: Colorectal cancer is the third most common cause of cancer-related deaths and the second most prevalent (after breast cancer) in the western world. High metastatic relapse rates and severe side effects associated with the adjuvant treatment have urged oncologists and clinicians to find a novel, less toxic therapeutic strategy. Considering the limited success of the past clinical trials involving peptide vaccine therapy to treat colorectal cancer, it is necessary to revise our knowledge of the immune system and its potential use in tackling cancer. This review presents the efforts of the scientific community in the development of peptide vaccine therapy for colorectal cancer. We review rec