perceiving molecular evolution processes in escherichia coli by comprehensive metabolite and gene expression profiling在大肠杆菌代谢物全面感知分子进化过程和基因表达分析.pdf

VijayendranVolume 9, Issue 4, Article R72et al.2008 Open Access Research Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling *† ‡ † ‡ Chandran Vijayendran , Aiko Barsch , Karl Friehs , Karsten Niehaus , Anke Becker‡ and Erwin Flaschel† Addresses: *International NRW Graduate School in Bioinformatics and Genome Research, Bielefeld University, D-33594 Bielefeld, Germany. †Fermentation Engineering Group, Bielefeld University, D-33594 Bielefeld, Germany. ‡Faculty of Biology, Bielefeld University, D-33594 Bielefeld, Germany. Correspondence: Chandran Vijayendran. Email: cvijayen@cebitec.uni-bielefeld.de Published: 10 April 2008 Received: 10 September 2007 Revised: 25 October 2007 Genome Biology 2008, 9:R72 (doi:10.1186/gb-2008-9-4-r72) Accepted: 10 April 2008 The electronic version of this article is the complete one and can be found online at /2008/9/4/R72 © 2008 Vijayendran et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ferent evolutionary conditions/pBacterial transcript and metabolite evolutionpTranscript and metabolite abundance changes were analyzed in evolved and ancestor strains of itEscherichia coli/it in three dif- Abstract Background: Evolutionary cha