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Behavioral and Brain Functions BioMed Central Research Open Access Persistent spatial working memory deficits in rats with bilateral cortical microgyria 1 2 3 1 R Holly Fitch* , Heather Breslawski , Glenn D Rosen and James J Chrobak Address: 1Department of Psychology/Behavioral Neuroscience, University of Connecticut, Storrs, CT, 06269, USA, 2Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA and 3Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave. Boston, MA, 02215, USA Email: R Holly Fitch* - roslyn.h.fitch@; Heather Breslawski - heather.breslawski@; Glenn D Rosen - grosen@; James J Chrobak - james.chrobak@ * Corresponding author Published: 1 October 2008 Received: 20 March 2008 Accepted: 1 October 2008 Behavioral and Brain Functions 2008, 4:45 doi:10.1186/1744-9081-4-45 This article is available from: /content/4/1/45 © 2008 Fitch et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Anomalies of cortical neuronal migration (e.g., microgyria (MG) and/or ectopias) are associated with a variety of language and cognitive deficits in human populations. In rodents, postnatal foca