pharmacological effects of radix angelica sinensis (danggui) on cerebral infarction药理作用的基数当归(danggui)在脑梗死.pdfVIP

Wu and Hsieh Chinese Medicine 2011, 6:32 /content/6/1/32 REVIEW Open Access Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction Yi-Chian Wu1 and Ching-Liang Hsieh1,2,3* Abstract Radix Angelica Sinensis, the dried root of Angelica sinensis (Danggui), is a herb used in Chinese medicine to enrich blood, promote blood circulation and modulate the immune system. It is also used to treat chronic constipation of the elderly and debilitated as well as menstrual disorders. Research has demonstrated that Danggui and its active ingredients, as anti-arthrosclerotic, anti-hypertensive, antioxidant anti-inflammatory agents which would limit platelet aggregation, are effective in reducing the size of cerebral infarction and improving neurological deficit scores. Background language database) between 1990 and 2010, using Danggui , the dried root of Angelica Sinensis (Radix ‘Angelica sinensis ’, ‘Danggui’, ‘Angelica polysaccharides’, Angelica Sinensis ), is a commonly used Chinese medic- ‘Z-Ligustilide’, ‘Ferulic acid’ and ‘Ischemic stroke’ as inal herb to enrich blood, promote blood circulation and keywords. treat blood deficiency pattern and menstrual disorders such as dysmenorrhea and irregular menstrual cycle [1]. Vasodilation and improving microcirculation Wilasrusmee et al. [2] reported that Danggui (105 μg/ml) Nitric oxide (NO) is synthesized with nitric oxide synthase plays an immunostimulatory role in mitogen-stimulated (NOS) which includes three different isoforms, namely murine lymphocytes in vitro. Angelan, a purified polysac- endothelial NOS (eNOS), neuronal NOS (nNOS) and charide component of A