pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor药效基因的选择和设计non-nucleotide炭疽水肿因子抑制剂.pdfVIP
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pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor药效基因的选择和设计non-nucleotide炭疽水肿因子抑制剂
Toxins 2012, 4, 1288-1300; doi:10.3390/toxins4111288
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Review
Pharmacophore Selection and Redesign of Non-nucleotide
Inhibitors of Anthrax Edema Factor
Catherine H. Schein 1,2,3,4,*, Deliang Chen 1, Lili Ma 5, John J. Kanalas 6, Jian Gao 6,
5 7 6 5
Maria Estrella Jimenez , Laurie E. Sower , Mary A. Walter , Scott R. Gilbertson ,
and Johnny W. Peterson 2,3
1 Sealy Center for Structural Biology and Molecular Biophysics, Department of Biochemistry and
Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA;
E-Mail: deliang2211!@
2 Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infections,
University of Texas Medical Branch, Galveston, TX 77555, USA; E-Mail: jpeterso@
3 Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston,
TX 77555, USA
4 Member, Institute for Translational Studies, and Faculty, Institute for Human Infection and
Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA
5 Department of Chemistry, University of Houston, Houston, TX 77004, USA;
E-Mails: mal1@ (L.M.); mestrell@ (M.E.J.);
srgilbe2@ (S.R.G.)
6 Mission Pharmacal Company, San Antonio, TX 78230, USA;
E-Mails: jkanalas@ (J.J.K.); jian.gao@ (J.G.);
mary.walter@ (M.A.W.)
7 Chrysalis Biotherapeutics, Galveston, TX 77555, USA; E-Mail: lauries806@
* Author to whom correspondence should be addressed; E-Mail: chschein@;
Tel.: +1-409-747-68
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