pathogenic mechanisms of idiopathic nonallergic rhinitis特发性nonallergic鼻炎的致病机制.pdfVIP

NAR CONSENSUS PANEL PROCEEDINGS, PART 1 Pathogenic Mechanisms of Idiopathic Nonallergic Rhinitis James N. Baraniuk, MD tion as found in chronic fatigue syndrome and other systemic Idiopathic nonallergic rhinitis (iNAR) has been difficult to define “functional” syndromes. because of the long differential diagnosis of rhinopathy in the absence of allergic rhinitis. iNAR has traditionally been a diagnosis ANATOMY AS DESTINY of exclusion with no clear unifying pathophysiology. Increased “Anatomy as destiny” may hold for people with nasal sensitivity to triggers such has climate changes, cold air, tobacco deformities and complaints but negative allergy skin tests. De- smoke, strong odors, and perfumes have been thought to be char- viated nasal septums are common findings. The deviations may acteristic, but recent studies do not support this hypersensitivity cause narrowing of the middle or inferior turbinate on the side of hypothesis. New investigations of the local nasal environment and the deviation, and hypertrophy of the turbinates into the space systemic “functional” syndromes have offered new insights into this vacated on the contralateral side.