pharmacological effects of salvia miltiorrhiza (danshen) on cerebral infarction丹参的药理作用(丹参)在脑梗死.pdfVIP

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pharmacological effects of salvia miltiorrhiza (danshen) on cerebral infarction丹参的药理作用(丹参)在脑梗死.pdf

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pharmacological effects of salvia miltiorrhiza (danshen) on cerebral infarction丹参的药理作用(丹参)在脑梗死

Lin and Hsieh Chinese Medicine 2010, 5:22 /content/5/1/22 R E V I E W Open Access Review Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction 1 1,2,3 Tsai-Hui Lin and Ching-Liang Hsieh* Abstract Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti- inflammatory and anti-oxidative effects. Review none and dihydrotan-shinone as well as the water-soluble Background danshensu and salvianolic acid B (Sal B) [9]. Danshen Danshen, the dried root of Salvia miltiorrhiza, is used in inhibits platelet aggregation and promotes fibrinolysis Chinese medicine to treat vascular disease. According to [10,11]. Chinese medicine theory, Danshen promotes blood flow Covering literature between 1990 and 2009, this article and resolves blood stasis. Among stroke patients, 80% reviews basic and clin