phenomir a knowledgebase for microrna expression in diseases and biological processesphenomir微rna表达的知识库疾病和生物过程.pdfVIP

Ruepp et al. Genome Biology 2010, 11:R6 /2010/11/1/R6 SOFTWARE Open Access PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes 1* 1 1,2 1 1 1 Andreas Ruepp , Andreas Kowarsch , Daniel Schmidl , Felix Buggenthin , Barbara Brauner , Irmtraud Dunger , 1 1 1 1,2* Gisela Fobo , Goar Frishman , Corinna Montrone , Fabian J Theis Abstract In recent years, microRNAs have been shown to play important roles in physiological as well as malignant pro- cesses. The PhenomiR database http://mips.helmholtz-muenchen.de/phenomir provides data from 542 studies that investigate deregulation of microRNA expression in diseases and biological processes as a systematic, manually curated resource. Using the PhenomiR dataset, we could demonstrate that, depending on disease type, indepen- dent information from cell culture studies contrasts with conclusions drawn from patient studies. Rationale cancer types solely by miRNA expression profiles MicroRNAs (miRNAs) are approximately 22-nucleotide [10,11]. In recent years, deregulated expression of endogenous RNAs predicted to regulate the expression miRNA has also been found to be associated with of most mammalian genes [1]. Since the discovery of human diseases such as cardiomyopathy, muscular dis- miRNAs in Caenorhabditis elegans, the influence of orders and neurodegenerative diseases [12-14]. The these regulatory RNAs on cellular processes has been