patterns of expression of vaginal t-cell activation markers during estrogen-maintained vaginal candidiasis阴道t细胞活化标志物的表达模式在estrogen-maintained阴道念珠菌病.pdfVIP

Original article Patterns of Expression of Vaginal T-Cell Activation Markers during Estrogen-Maintained Vaginal Candidiasis Ameera Al-Sadeq, MSc, Mawieh Hamad, PhD, and Khaled Abu-Elteen, PhD the immunosuppressive activity of estrogen was further investigated by assessing the pattern of expression of cD25, cD28, cD69, and cD152 on vaginal t cells during estrogen-maintained vaginal candidiasis. a precipitous and signiicant decrease in vaginal fungal burden toward the end of week 3 postinfection was concurrent with a signiicant increase in vaginal lymphocyte numbers. During this + + + + + period, the percentage of cD3 , cD3 cD4 , cD152 , and cD28 vaginal t cells gradually and signiicantly increased. the percentage of + + + + cD3 and cD3 cD4 cells increased from 43% and 15% at day 0 to 77% and 40% at day 28 postinfection. compared with 29% cD152 + vaginal t cells in naive mice, 70% of vaginal t cells were cD152 at day 28 postinfection. in conclusion, estrogen-maintained vaginal candidiasis results in postinfection time-dependent changes in the pattern of expression of cD152, cD28, and other t-cell markers, suggesting that t cells are subject to mixed suppression and activation signals. Key words: CD28, CD152, estrogen, vaginal candidiasis, vaginal T lymphocytes aginal candidiasis (VC) is now recognized as a ma- immune responses converge to protect the host against fun- Vjor health problem for women of childbearing age gal infections (reviewed in Romani15). Intact epithelia and en- worldwide.1,2 The majority of genitourinary trac