pcr based bronchoscopic detection of common respiratory pathogens in chronic cough a case control study基于pcr的支气管镜的常见呼吸道病原体的检测在慢性咳嗽一个病例对照研究.pdfVIP

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pcr based bronchoscopic detection of common respiratory pathogens in chronic cough a case control study基于pcr的支气管镜的常见呼吸道病原体的检测在慢性咳嗽一个病例对照研究.pdf

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pcr based bronchoscopic detection of common respiratory pathogens in chronic cough a case control study基于pcr的支气管镜的常见呼吸道病原体的检测在慢性咳嗽一个病例对照研究

West et al. Cough 2012, 8:5 /content/8/1/5 Cough RESEARCH Open Access PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study 1,2 1,2 1 3 4 5 Peter W West , Angela Kelsall , Samantha Decalmer , Winifred Dove , Paul W Bishop , James P Stewart , Ashley A Woodcock1,2 and Jaclyn A Smith1,6* Abstract Background: Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanation for the cough reflex hypersensitivity and pulmonary inflammation reported in chronic cough patients. Methods: Bronchoscopic endobronchial biopsies and bronchoalveolar lavage cell counts were obtained from ten healthy volunteers and twenty treatment resistant chronic cough patients (10 selected for lavage lymphocytosis). A screen for known respiratory pathogens was performed on biopsy tissue. Chronic cough patients also underwent cough reflex sensitivity testing using citric acid. Results: There was no significant difference in incidence of infection between healthy volunteers and chronic cough patients (p = 0.115) or non-lymphocytic and lymphocytic groups (p = 0.404). BAL cell percentages were not significantly different between healthy volunteers and chronic cough patients without lymphocytosis. Lymphocytic patients however had a significantly raised percentage of lymphocytes (p 0.01), neutrophils (p 0.05), eosinophils (p 0.05) and decreased macrophages (p 0.001) verses healthy volunteers. There was no significant difference in the coug