physical carboxymethylscleroglucancalcium ion hydrogels as modified drug delivery systems in topical formulations物理carboxymethylscleroglucancalcium离子水凝胶作为药物输送系统局部修改配方.pdf

Molecules 2009, 14, 2684-2698; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations 1 1 1 2 2 Federica Corrente , Pietro Matricardi , Patrizia Paolicelli , Beatrice Tita , Federica Vitali and Maria Antonietta Casadei 1,* 1 Dipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy 2 Dipartimento di Fisiologia e Farmacologia, “Sapienza” Università di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy * Author to whom correspondence should be addressed; E-mail: mariaantonietta.casadei@uniroma1.it Received: 29 June 2009; in revised form: 16 July 2009/ Accepted: 21 July 2009 / Published: 24 July 2009 Abstract: A carboxymethyl derivative of scleroglucan (Scl-CM) with a 65±5% carboxylic group degree of derivatization (DD) was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2 . Physical hydrogels with different Scl-CM/Ca+2 ratios were prepared and characterized for their rheological behaviour. Their potential as drug delivery systems was also evaluated. To this end three non steroidal anti- inflammatory drugs (NSAIDs) were