placental mesenchymal dysplasia, a case of intrauterine sudden death of fetus with rupture of cirsoid periumbilical chorionic vessels胎盘间充质发育异常,子宫内的胎儿猝死的曲张的脐绒毛膜血管破裂.pdfVIP

Umazume et al. Diagnostic Pathology 2011, 6:38 /content/6/1/38 CASE REPORT Open Access Placental mesenchymal dysplasia, a case of intrauterine sudden death of fetus with rupture of cirsoid periumbilical chorionic vessels Takeshi Umazume 1†, Soromon Kataoka1*†, Kyouko Kamamuta1†, Fumie Tanuma1†, Akihiko Sumie1†, Toru Shirogane 1†, Takayuki Kudou1† and Hitoshi Ikeda2† Abstract We report a 32-year-old woman (1-gravid, 1-para) with a vesicular lesion in her uterus that was pointed out on ultrasound at 8 weeks’ gestation. Amniocentesis at 15 weeks’ gestation showed a normal female karyotype, 46XX. As the pregnancy advanced, the mole-like lesion became relatively reduced. Throughout gestation, the maternal human chorionic gonadotropin level was normal, but the serum alpha fetoprotein level rose as her pregnancy progressed. Her fetus did not exhibit any remarkable anomalies. The patient visited our hospital complaining of a diminished feeling of fetal movements at 36 weeks 5 days’ gestation, and intrauterine fetal death (IUFD) was confirmed. She delivered a 2336-g female without any definite anomalies. A pathological examination led to a diagnosis of placental mesenchymal dysplasia, and androgenetic/biparental mosaicism in the placenta was identified using p57kip2 immunohistochemical staining. And it also revealed that the rupture of the cirsoid chorionic vessels had led to IUFD. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/1030203924510721. Background kinds of vascular anomalies, such as cirsoid chorionic ves- Placental mesenchymal dysplasia (PMD) is a rare placental sels, thrombosis, thickness of vessel wall, vascular stenosis, anomaly characterized by placentomegaly an