pharmacokinetics of recombinant human growth hormone administered by cool.click? 2, a new needle-free device, compared with subcutaneous administration using a conventional syringe and needle重组人生长激素的药物由酷。.pdfVIP
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pharmacokinetics of recombinant human growth hormone administered by cool.click? 2, a new needle-free device, compared with subcutaneous administration using a conventional syringe and needle重组人生长激素的药物由酷。
BMC Clinical Pharmacology BioMed Central
Research article Open Access
Pharmacokinetics of recombinant human growth hormone
administered by cool.click™ 2, a new needle-free device, compared
with subcutaneous administration using a conventional syringe and
needle
1 2 2
Chris Brearley , Anthony Priestley , James Leighton-Scott and
Michel Christen*3
Address: 1Clinical Research, Serono International SA, 1211 Geneva, Swizerland, 2LCG Bioscience, Bourn Hall, Bourn, Cambridge CB3 7TR, UK
and 3Patients Care Technologies Center of Expertise, Merck Serono International SA, 1211 Geneva, Switzerland
Email: Chris Brearley - chrisbrearley@.uk; Anthony Priestley - anthony.priestley@LCG-Bourn.co.uk; James Leighton-
Scott - drJames.Leighton-Scott@napp.co.uk; Michel Christen* - michel.christen@
* Corresponding author
Published: 8 October 2007 Received: 8 December 2006
Accepted: 8 October 2007
BMC Clinical Pharmacology 2007, 7:10 doi:10.1186/1472-6904-7-10
This article is available from: /1472-6904/7/10
© 2007 Brearley et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Growth hormone (GH) is used to treat growth hormone deficiency (GHD, adult and paediatric), short
bowel syndrome in patients on a specialized diet, HIV-associated wasting and, in children, growth failure due to a
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