pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis b a case report病理性股骨骨折由于骨软化与阿德福伟治疗乙型肝炎病例报告.pdfVIP

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pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis b a case report病理性股骨骨折由于骨软化与阿德福伟治疗乙型肝炎病例报告.pdf

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pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis b a case report病理性股骨骨折由于骨软化与阿德福伟治疗乙型肝炎病例报告

Tanaka et al. Diagnostic Pathology 2012, 7:108 /content/7/1/108 CASE REPORT Open Access Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report 1 2* 3 1 1 1 Motoyuki Tanaka , Takao Setoguchi , Yasuhiro Ishidou , Yoshiya Arishima , Masataka Hirotsu , Yoshinobu Saitoh , 1 1 1 1 1 Shunsuke Nakamura , Hironori Kakoi , Satoshi Nagano , Masahiro Yokouchi , Junichi Kamizono and Setsuro Komiya1 Abstract We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. He had a 13-month history of bone pain involving his shoulders, hips, and knee. He received adefovir dipivoxil for treatment of lamivudine-resistant hepatitis B virus infection for 5 years before the occurrence of femoral neck fracture. Orthopedic surgeons should be aware of osteomalacia and pathological hip fracture caused by drug-induced renal dysfunction, which results in Fanconi’s syndrome. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/1600344696739249 Keywords: Osteomalacia, Pathological femoral neck fracture, Adefovir dipivoxil, Hepatitis B, Fanconi’s syndrome Background a clinic and was administered salazosulfapyridine and Hypophosphatemic osteomalacia caused by proximal methylprednisolone therapy for rheumatoid arthritis. renal tubule dys