pharmacological and ischemic preconditioning of the human myocardium mitokatp channels are upstream and p38mapk is downstream of pkc药理和人类心肌的缺血性预处理mitokatp渠道上游和p38mapk pkc的下游.pdfVIP

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pharmacological and ischemic preconditioning of the human myocardium mitokatp channels are upstream and p38mapk is downstream of pkc药理和人类心肌的缺血性预处理mitokatp渠道上游和p38mapk pkc的下游.pdf

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pharmacological and ischemic preconditioning of the human myocardium mitokatp channels are upstream and p38mapk is downstream of pkc药理和人类心肌的缺血性预处理mitokatp渠道上游和p38mapk pkc的下游

BMC Physiology BioMed Central BMC Physiology x 2002, 2 Research article Pharmacological and ischemic preconditioning of the human myocardium: mitoKATP channels are upstream and p38MAPK is downstream of PKC Mahmoud Loubani and Manuel Galiñanes * Address: Department of Integrative Human Cardiovascular Physiology and Functional Genomics, Division of Cardiac Surgery, University of Leicester, Glenfield Hospital, Groby Road, Leicester E-mail: Mahmoud Loubani - mahmoud.loubani@; Manuel Galiñanes* - mg50@le.ac.uk *Corresponding author Published: 18 July 2002 Received: 3 May 2002 Accepted: 18 July 2002 BMC Physiology 2002, 2:10 This article is available from: /1472-6793/2/10 © 2002 Loubani and Galiñanes; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any pur- pose, provided this notice is preserved along with the articles original URL. Abstract Background: These studies investigate the role of mitoKATP channels, protein kinase C (PKC) and Mitogen activated protein kinase (p38MAPK) on the cardioprotection of ischemic (IP) and pharmacological preconditioning (PP) of the human myocardium and their sequence of activation. Results: Right atrial appendages from patients undergoing elective cardiac surgery were equilibrated for 30 min and then subjected to 90 min of simulated ischemia followed by 120 min reoxygenation. At the end of each protocol creatinine kinase leakage (CK U/g wet wt) and the reduction of MTT to formazan dye (mM/g wet wt) w