polymicrobial endophthalmitis prevalence, causative organisms, and visual outcomespolymicrobial眼内炎发病率、病因生物和视觉效果.pdf

Jindal et al. Journal of Opthalmic Inflammation and Infection 2013, 3:6 /content/3/1/6 ORIGINAL RESEARCH Open Access Polymicrobial endophthalmitis: prevalence, causative organisms, and visual outcomes 1 2 1* 1 2 2 Animesh Jindal , Mayur R Moreker , Avinash Pathengay , Manav Khera , Subhadra Jalali , Ajit Majji , 2 3 3 4 Annie Mathai , Savitri Sharma , Taraprasad Das and Harry W Flynn Jr Abstract Background: The purpose of the present study is to evaluate the prevalence, causative organisms, and visual acuity outcome in patients with culture-proven polymicrobial endophthalmitis. The method used in this study is the non- comparative, consecutive case series using a retrospective analysis of patients diagnosed with polymicrobial endophthalmitis for the period 2000 to 2010. Results: Polymicrobial endophthalmitis was identified in 43/1,107 (3.88%) patients. Forty-two patients had two isolates, and one patient had grown three isolates, yielding a total of 87 isolates. Gram-positive cocci were the most common isolate (n = 53; 60.9%) including Staphylococcus epidermidis (n = 14/53; 16.1%) and Streptococcus pneumoniae (n = 13/53; 13.8%). The etiologies included posttraumatic (n = 31/43; 72.1%) and postoperative (n = 9/43; 20.9%) endophthalmitis. Antibiotic susceptibilities among Gram-positive bacteria were vancomycin (100%) and chloramphenicol (96%). Susceptibilities among Gram-negative bacteria were ciprofloxacin (86.4%) and ofloxacin (81.2%). A maximum number of secondary interventions were done in traumatic cases (38.7%) and cases having coinfection with Gram-negative bacteria and fungus (66.7%). Visu