potential vaccines and post-exposure treatments for filovirus infections潜在的疫苗和接触后治疗filovirus感染.pdfVIP

Viruses 2012, 4, 1619-1650; doi:10.3390/v4091619 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Potential Vaccines and Post-Exposure Treatments for Filovirus Infections Brian M. Friedrich 1,†, John C. Trefry 1,†, Julia E. Biggins 1, Lisa E. Hensley 2, Anna N. Honko 1, Darci R. Smith 1 and Gene G. Olinger 1,* 1 United States Army Medical Research Institute of Infectious Diseases, Division of Virology, 1425 Porter Street, Frederick, MD 21702, USA; E-Mails: brian.m.friedrich.ctr@ (B.M.F.); john.c.trefry.ctr@ ( J.C.T.); julia.biggins@ ( J.E.B.); anna.honko@ (A.N.H.); darci.smith1@ (D.R.S.) 2 United States Food and Drug Administration (FDA), Medical Science Countermeasures Initiative (McMi), 10903 New Hampshire Avenue, Silver Spring, MD 2090 1, USA; E-Mail: lisa.hensley@ † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: Gene.olinger@; Tel.: +1-301-619-8581. Received: 20 July 2012; in revised form: 31 August 2012 / Accepted: 4 September 2012 / Published: 21 September 2012 Abstract: Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral infection, there remain no sanctioned therapeutic or vaccine strategies. Current progress in the development of filovirus therapeutics and vaccines is outlined herein with respect to