polar compounds isolated from the leaves of albertisia delagoensis (menispermaceae)极性化合物分离的叶子albertisia delagoensis(防己科).pdfVIP

Molecules 2011, 16, 9153-9160; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Polar Compounds Isolated from the Leaves of Albertisia delagoensis (Menispermaceae) Geoffrey E. Hawkes 1, Helene de Wet 2,* and Jia Li 3 1 School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK 2 Department of Botany, University of Zululand, P/Bag X1001, Kwa-Dlangezwa 3880, South Africa 3 Department of Surgery and Cancer, Imperial College London, South Kensington Campus, London SW7 2AZ, UK * Author to whom correspondence should be addressed; E-Mail: hdewet@pan.uzulu.ac.za; Tel.: +27-35-902-6108; Fax: +27-35-902-6391. Received: 8 October 2011; in revised form: 21 October 2011 / Accepted: 27 October 2011 / Published: 2 November 2011 Abstract: Aqueous infusions of the leaves of the shrub Albertisia delagoensis (Menispermaceae) are used in South Africa in traditional Zulu medicine to alleviate a variety of symptoms, including fever, and intestinal problems. We report the analysis of such an aqueous extract using the HPLC-NMR technique. A number of polar compounds were identified, including proto -quercitol, nicotinic acid, allantoic acid, 3,4-dihydroxy- benzoic acid, phthalic acid and the aporphine alkaloid derivative roemrefidine. Allantoic acid and roemrefidine have been fully characterised by 1H- and 13C-NMR and mass spectrometry. Earlier r