pr3-anca in wegeners granulomatosis prime human mononuclear cells for enhanced activation via tlrs and nod12pr3-anca韦格纳肉芽肿病的主要人类单核细胞增强激活通过通常和nod12.pdfVIP

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pr3-anca in wegeners granulomatosis prime human mononuclear cells for enhanced activation via tlrs and nod12pr3-anca韦格纳肉芽肿病的主要人类单核细胞增强激活通过通常和nod12.pdf

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pr3-anca in wegeners granulomatosis prime human mononuclear cells for enhanced activation via tlrs and nod12pr3-anca韦格纳肉芽肿病的主要人类单核细胞增强激活通过通常和nod12

Diagnostic Pathology BioMed Central Research Open Access PR3-ANCA in Wegeners granulomatosis prime human mononuclear cells for enhanced activation via TLRs and NOD1/2 Akiko Uehara*, Tadasu Sato, Atsushi Iwashiro and Sou Yokota Address: Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Sendai, Japan Email: Akiko Uehara* - kyoro@mail.tains.tohoku.ac.jp; Tadasu Sato - kyoro@mail.tains.tohoku.ac.jp; Atsushi Iwashiro - kyoro@mail.tains.tohoku.ac.jp; Sou Yokota - kyoro@mail.tains.tohoku.ac.jp * Corresponding author Published: 14 July 2009 Received: 2 June 2009 Accepted: 14 July 2009 Diagnostic Pathology 2009, 4:23 doi:10.1186/1746-1596-4-23 This article is available from: /content/4/1/23 © 2009 Uehara et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Anti-neutrophil cytoplasmic antibodies (ANCA) is autoantibodies characteristic of vasculitis diseases. A connection between ANCA and Wegeners granulomatosis was well established. The interaction of both ANCA phenotypes (PR3-ANCA and MPO-ANCA) with leukocytes provoked cell activation, which might be involved in the pathogenesis of ANCA-related Wegeners granulomatosis. Methods: In this study, we examined wheth