prediction of synergistic transcription factors by function conservation协同预测转录因子的功能保护.pdfVIP

Volume 8, Issue 12, Article R257et al.Hu2007 Open Access Method Prediction of synergistic transcription factors by function conservation * † ‡ Zihua Hu , Boyu Hu and James F Collins Addresses: *Center for Computational Research, New York State Center of Excellence in Bioinformatics and Life Sciences, Department of Biostatistics, Department of Medicine, University at Buffalo, State University of New York (SUNY), Buffalo, NY 14260, USA. †Duke University, Durham, NC 27710, USA. ‡Department of Exercise and Nutrition Sciences, University at Buffalo, State University of New York (SUNY), Buffalo, NY 14260, USA. Correspondence: Zihua Hu. Email: zihuahu@ Published: 5 December 2007 Received: 28 May 2007 Revised: 19 October 2007 Genome Biology 2007, 8:R257 (doi:10.1186/gb-2007-8-12-r257) Accepted: 5 December 2007 The electronic version of this article is the complete one and can be found online at /2007/8/12/R257 © 2007 Hu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. homotypic transcription-factor combinations./pSynergistic transcription factorspA new strategy is proposed for identifying synergistic transcription factors by function conservation, leading to the identification of 51 Abstract Background: Previous methods employed for the identification of synergistic transcription