predictive value of igeigg4 antibody ratio in children with egg allergy预测价值igeigg4抗体的比例对鸡蛋过敏的儿童.pdfVIP

Okamoto et al. Allergy, Asthma Clinical Immunology 2012, 8:9 /content/8/1/9 ALLERGY, ASTHMA CLINICAL IMMUNOLOGY RESEARCH Open Access Predictive value of IgE/IgG4 antibody ratio in children with egg allergy * Shindou Okamoto, Shoichiro Taniuchi , Kyoko Sudo, Yasuko Hatano, Keiji Nakano, Tomohiko Shimo and Kazunari Kaneko Abstract Background: The aim of this study was to investigate the role of specific IgG4 antibodies to hen’s egg white and determine their utility as a marker for the outcome of oral challenge test in children sensitized to hen’s egg Methods: The hen’s egg oral food challenge test was performed in 105 sensitized children without atopic dermatitis, and the titers of egg white-specific immunoglobulin G (IgG ) and immunoglobulin E (IgE) antibodies 4 4 were measured. To set the cut-off values of IgG4, IgE, and the IgE/IgG4 ratio for predicting positive results in oral challenges, receiver operating characteristic curves were plotted and the area under the curves (AUC) were calculated. Results: Sixty-four of 105 oral challenges with whole eggs were assessed as positive. The AUC for IgE, IgG4, and IgE/IgG4 for the prediction of positive results were 0.609, 0.724, and 0.847, respectively. Thus, the IgE/IgG4 ratio generated significantly higher specificity, sensitivity, positive predictive value (%), and negative predictive value (%) than the individual IgE and IgG4. The negative predictive value of the IgE/IgG4 ratio was 90% at a value of 1. Conclusions: We have demonstrated t