pre-treatment mortality and loss-to-follow-up in hiv-1, hiv-2 and hiv-1hiv-2 dually infected patients eligible for antiretroviral therapy in the gambia, west africa预处理死亡率和loss-to-follow-up在hiv - 1、hiv - 2和hiv-1hiv-2双重感染患者获得抗逆转录病毒疗法在冈比亚,西非.pdfVIP

Togun et al. AIDS Research and Therapy 2011, 8:24 /content/8/1/24 RESEARCH Open Access Pre-treatment mortality and loss-to-follow-up in HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients eligible for antiretroviral therapy in The Gambia, West Africa 1* 2 3 1 1 1,4 1,5 Toyin Togun , Ingrid Peterson , Shabbar Jaffar , Francis Oko , Uduak Okomo , Kevin Peterson and Assan Jaye Abstract Background: High early mortality rate among HIV infected patients following initiation of antiretroviral therapy (ART) in resource limited settings may indicate high pre-treatment mortality among ART-eligible patients. There is dearth of data on pre-treatment mortality in ART programmes in sub-Sahara Africa. This study aims to determine pre-treatment mortality rate and predictors of pre-treatment mortality among ART-eligible adult patients in a West Africa clinic-based cohort. Methods: All HIV-infected patients aged 15 years or older eligible for ART between June 2004 and September 2009 were included in the analysis. Assessment for eligibility was based on the Gambia ART guideline. Survival following ART-eligibility was determined by Kaplan-Meier estimates and predictors of pre-treatment mortality determined by Cox proportional hazard models. Result: Overall, 790 patients were assessed as eligible for ART based on their clinical and/or immunological status among whom 510 (64.6%) started treatment, 26 (3.3%) requested transfer to another health facility, 136 (17.2%) and 118 (14.9%) were lost to follow-up and died respectively without starting ART. ART-eligible patients who died or were lost to follow-up were more likely to be male or to have a CD4 T-cell count 100 cells/μL, wh