prediction model for knee osteoarthritis based on genetic and clinical information预测模型对膝骨关节炎基于遗传和临床信息.pdfVIP

Takahashi et al. Arthritis Research Therapy 2010, 12:R187 /content/12/5/R187 RESEARCH ARTICLE Open Access Prediction model for knee osteoarthritis based on genetic and clinical information 1 2 3 3 1 2* Hiroshi Takahashi , Masahiro Nakajima , Kouichi Ozaki , Toshihiro Tanaka , Naoyuki Kamatani , Shiro Ikegawa Abstract Introduction: Osteoarthritis (OA) is the most common bone and joint disease influenced by genetic and environmental factors. Recent association studies have uncovered the genetic factors behind OA, its susceptibility genes, which would enable us to predict disease occurrence based on genotype information. However, most previous studies have evaluated the effects of only a single susceptibility gene, and hence prediction based on such information is not as reliable. Here, we constructed OA-prediction models based on genotype information from a case-control association study and tested their predictability. Methods: We genotyped risk alleles of the three susceptibility genes, asporin (ASPN), growth differentiation factor 5 (GDF5), and double von Willebrand factor A domains (DVWA) for a total of 2,158 Japanese subjects (933 OA and 1,225 controls) and statistically analyzed their effects. After that, we constructed prediction models by using the logistic regression analysis. Results: When the effects of each allele were assumed to be the same and multiplicative, each additional risk allele increased the odds ratio (OR) by a factor of 1.23 (95% confidence interval (CI), 1.12 to 1.34). Individuals with five or six risk alleles showed significantly higher susceptibility when compared with those with zero or one, with an OR of 2.67 (95% CI, 1.46 to 4.87; P = 0.0020). Statistical ev