原创力文档polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma a case control study两个histamine-metabolizing酶基因的多态性与儿童过敏性哮喘病例对照研究.pdf
- 1、本文档共6页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma a case control study两个histamine-metabolizing酶基因的多态性与儿童过敏性哮喘病例对照研究
Szczepankiewicz et al. Clinical and Molecular Allergy 2010, 8:14
/content/8/1/14
CMA
RESEARCH Open Access
Polymorphisms of two histamine-metabolizing
enzymes genes and childhood allergic asthma:
a case control study
1* 2 2 2
Aleksandra Szczepankiewicz , Anna Bręborowicz , Paulina Sobkowiak , Anna Popiel
Abstract
Background: Histamine-metabolizing enzymes (N-methyltransferase and amiloride binding protein 1) are
responsible for histamine degradation, a biogenic amine involved in allergic inflammation. Genetic variants of
HNMT and ABP1 genes were found to be associated with altered enzyme activity. We hypothesized that alleles
leading to decreased enzyme activity and, therefore, decreased inactivation of histamine may be responsible for
altered susceptibility to asthma.
Methods: The aim of this study was to analyze polymorphisms within the HNMT and ABP1 genes in the group of
149 asthmatic children and in the group of 156 healthy children. The genetic analysis involved four polymorphisms
of the HNMT gene: rs2071048 (-1637T/C), r(-411C/T), rs1801105 (Thr105Ile = 314C/T) and rs1050891
(1097A/T) and rs1049793 (His645Asp) polymorphism for ABP1 gene. Genotyping was performed with use of PCR-
RFLP. Statistical analysis was performed using Statistica software; linkage disequilibrium analysis was done with use
of Haploview software.
Results: We found an association of TT genotype and T allele of Thr105Ile polymorphism of HNMT gene with
asthma. For other polymorphisms for HNMT and ABP1 genes, we have not observed relationship with asthma
although the statistical power for some SNPs might not have been sufficien
您可能关注的文档
- physicochemical characterization and cytotoxic activity evaluation of hydroxymethylferroceneβ-cyclodextrin inclusion complex物理化学表征、活性细胞毒性评价hydroxymethylferroceneβ-cyclodextrin包含复杂.pdf
- physicochemical properties and antioxidant activities of luteolin-phospholipid complex理化性质和抗氧化剂luteolin-phospholipid复杂的活动.pdf
- physicochemical characteristics and immunomodulatory activities of three polysaccharide-protein complexes of longan pulp三个polysaccharide-protein复合物的理化特征和免疫调节活动桂圆肉.pdf
- physiological and molecular characterization of aluminum resistance in medicago truncatula生理和分子特征medicago truncatula铝电阻.pdf
- physicochemical properties, in vitro antioxidant activities and inhibitory potential against α-glucosidase of polysaccharides from ampelopsis grossedentata leaves and stems物理化学性质、体外抗氧化活性和抑制潜在反对α-glucosidase多糖蛇葡萄属grossedentata叶子和茎.pdf
- physiological responses of daphnia pulex to acid stress水蚤pulex酸压力的生理反应.pdf
- physiological-biochemical and molecular-genetic bases of increasing milk production生理生化学和分子遗传基础增加牛奶产量.pdf
- physiological-dose steroid therapy in sepsis [isrctn36253388]生理剂量类固醇治疗脓毒症(isrctn36253388).pdf
- physiological studies in heterozygous calcium sensing receptor (casr) gene-ablated mice confirm that the casr regulates calcitonin release in vivo杂合的生理研究钙敏感受体(casr)gene-ablated老鼠确认casr调节体内降钙素的释放.pdf
- physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated t-cells 5 in vitro生理紧张性改善人类chondrogenic标记表达式通过核转录因子的激活t细胞5体外.pdf
文档评论（0）