physicochemical characterization and cytotoxic activity evaluation of hydroxymethylferroceneβ-cyclodextrin inclusion complex物理化学表征、活性细胞毒性评价hydroxymethylferroceneβ-cyclodextrin包含复杂.pdf

Molecules 2012, 17, 6056-6070; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Physicochemical Characterization and Cytotoxic Activity Evaluation of Hydroxymethylferrocene:β-Cyclodextrin Inclusion Complex Rosa Iacovino 1,*, Jolanda Valentina Caso 1, Filomena Rapuano 2, Agostino Russo 1, 3 3 1 1 Marina Isidori , Margherita Lavorgna , Gaetano Malgieri and Carla Isernia 1 Department of Environmental Science, Second University of Naples, via A.Vivaldi 43, 81100 Caserta, Italy; E-Mails: valentina.caso@unina2.it (J.V.C.); agostino.russo@unina2.it (A.R.); gaetano.malgieri@unina2.it (G.M.); carla.isernia@unina2.it (C.I.) 2 Department of Biological and Environmental Science, University of Sannio, via PortArsa, 11, 82100 Benevento, Italy; E-Mail: filomena.rapuano@unisannio.it 3 Department of Life Sciences, Second University of Naples, via A.Vivaldi 43, 81100 Caserta, Italy; E-Mails: marina.isidori@unina2.it (M.I.); margherita.lavorgna@unina2.it (M.L.) * Author to whom correspondence should be addressed; E-Mail: rosa.iacovino@unina2.it; Tel.: +39-082-3274-663; Fax: +39-082-3274-605. Received: 24 April 2012; in revised form: 14 May 2012 / Accepted: 15 May 2012 / Published: 21 May 2012 Abstract: An inclusion complex of hydroxymethylferrocene (FeMeOH) with β-cyclodextrin (β-CD) was prepared in the solid state by different techniques such as physical