physiological studies in heterozygous calcium sensing receptor (casr) gene-ablated mice confirm that the casr regulates calcitonin release in vivo杂合的生理研究钙敏感受体(casr)gene-ablated老鼠确认casr调节体内降钙素的释放.pdf

BMC Physiology BioMed Central Research article Open Access Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo Neva J Fudge and Christopher S Kovacs* Address: Faculty of Medicine – Endocrinology, Memorial University of Newfoundland, St. Johns, Newfoundland, A1B 3V6 Canada Email: Neva J Fudge - nevafudge@; Christopher S Kovacs* - ckovacs@mun.ca * Corresponding author Published: 20 April 2004 Received: 09 January 2004 Accepted: 20 April 2004 BMC Physiology 2004, 4:5 This article is available from: /1472-6793/4/5 © 2004 Fudge and Kovacs; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Animal models/rodentcalcitoninfamilial hypocalciuric hypocalcemiacalcium receptorgene knock-out Abstract Background: The calcium sensing receptor (CaSR) regulates serum calcium by suppressing secretion of parathyroid hormone; it also regulates renal tubular calcium excretion. Inactivating mutations of CaSR raise serum calcium and reduce urine calcium excretion. Thyroid C-cells (which make calcitonin) express CaSR and may, therefore, be regulated by it. Since calcium stimulates release of calcitonin, the higher blood calcium caused by inactivation of CaSR should increase serum calcitonin, u