periodic assessment of plasma sflt-1 and plgf concentrations and its association with placental morphometry in gestational hypertension (gh) - a prospective follow-up study定期评估等离子sflt-1和plgf浓度及其在妊娠期高血压与胎盘形态测量学(gh)u2014u2014一个前瞻性随访研究.pdf

Jeevaratnam et al. BMC Pregnancy and Childbirth 2010, 10:58 /1471-2393/10/58 RESEARCH ARTICLE Open Access Periodic assessment of plasma sFlt-1 and PlGF concentrations and its association with placental morphometry in gestational hypertension (GH) - a prospective follow-up study 1,2 2* 2 3 4 Kamalan Jeevaratnam , Vishna Devi Nadarajah , John Paul Judson , Sivalingam Nalliah , Mohd Farouk Abdullah Abstract Background: Hypertensive disorders in pregnancy contributes to about 12% of maternal deaths in Malaysia and similarly worldwide. Early detection and adequate management are preventable strategies. Biochemical markers of abnormal angiogenesis would be more specific in early detection than routine blood pressure and proteinuria measurements. The aim of this study was to estimate maternal plasma PlGF and sFlt-1 levels in pregnant women with gestational hypertension at three intervals of pregnancy and correlate these biomarker levels with placental morphometry. Methods: Venous blood samples (antepartum, intrapartum and post partum periods) were drawn to estimate for sFlt-1 and PlGF levels while placental tissue samples were examined for placental morphometry. Results: PlGF levels were lower in gestational hypertension (GH) compared to normotensive during antepartum and intrapartum period, whereas sFlt-1 levels were elevated in GH at antepartum, intrapartum and postpartum intervals during pregnancy. An inverse relationship between these two biomarkers was observed through correlation analysis. PlGF levels were inversely correlated with total villous surface area of the placental periphery (TCsa-C) and villous capillarization (VC-C) of the placental periphery. Conclusion: We esta