原创力文档prioritizing functional modules mediating genetic perturbations and their phenotypic effects a global strategy优先级功能模块协调遗传扰动和他们的表型影响全球战略.pdfVIP
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prioritizing functional modules mediating genetic perturbations and their phenotypic effects a global strategy优先级功能模块协调遗传扰动和他们的表型影响全球战略
Volume 9, Issue 12, Article R174Wanget al.2008 Open Access
Method
Prioritizing functional modules mediating genetic perturbations
and their phenotypic effects: a global strategy
* *† *
Li Wang , Fengzhu Sun and Ting Chen
Addresses: *Molecular and Computational Biology, Department of Biology Sciences, University of Southern California, 1050 Childs Way, Los
Angeles, CA 90089-2910, USA. †MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation,
Tsinghua University, Beijing 100084, PR China.
Correspondence: Ting Chen. Email: tingchen@
Published: 16 December 2008 Received: 5 August 2008
Revised: 11 November 2008
Genome Biology 2008, 9:R174 (doi:10.1186/gb-2008-9-12-r174)
Accepted: 16 December 2008
The electronic version of this article is the complete one and can be
found online at /2008/9/12/R174
© 2008 Wang et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
didate modules./pPrioritizing functional modulespA strategy is presented to prioritize the functional modules that mediate genetic perturbations and their phenotypic effects among can-
Abstract
We have developed a global strategy based on the Bayesian network framework to prioritize the
functional modules mediating genetic perturbations and their phenotypic effects among a set of
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