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progress in the studies on rutaecarpinerutaecarpine研究进展
Molecules 2008, 13, 272-300
molecules
ISSN 1420-3049
© 2008 by MDPI
/molecules
Review
Progress in the Studies on Rutaecarpine
Seung Ho Lee, Jong-Keun Son, Byeong Seon Jeong, Tae-Cheon Jeong, Hyeon Wook Chang,
Eung-Seok Lee and Yurngdong Jahng *
College of Pharmacy, Yeungnam University, Gyeongsan 712-749 Korea
* Author to whom correspondence should be addressed; E-mail: ydjahng@ynu.ac.kr
Received: 1 January 2008; in revised form 1 February 2008 / Accepted: 2 February 2008 / Published:
6 February 2008
Abstract: Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia
rutaecarpa and related herbs, which has shown a variety of intriguing biological properties
such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and
thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and
endocrine systems. Recent progress in the studies on the isolation, synthesis, structure-
activity relationship studies, biological activities and metabolism of rutaecarpine are
reviewed.
Keywords: Alkaloid, Rutaceae, rutaecarpine.
1. Introduction
Herbs have been widely employed as important remedies all over the world [1]. Progress in science
and technology in recent decades has made possible not only to isolate and characterize the
biologically active constituents of herbs, but also to evaluate their biological activities. Rutaceous
plants, especially
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