原创力文档prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections预测激素原的不良医疗结果在社区获得性肺炎和下呼吸道感染.pdfVIP
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prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections预测激素原的不良医疗结果在社区获得性肺炎和下呼吸道感染
Schuetz et al. Critical Care 2010, 14:R106
/content/14/3/R106
R E S E A R C H Open Access
Research
Prohormones for prediction of adverse medical
outcome in community-acquired pneumonia and
lower respiratory tract infections
†1 †2,3 1 1,4 1,5
Philipp Schuetz , Marcel Wolbers , Mirjam Christ-Crain , Robert Thomann , Claudine Falconnier ,
6 6 7 8 1 9
Isabelle Widmer , Stefanie Neidert , Thomas Fricker , Claudine Blum , Ursula Schild , Nils G Morgenthaler ,
4 6 8 7 7 2
Ronald Schoenenberger , Christoph Henzen , Thomas Bregenzer , Claus Hoess , Martin Krause , Heiner C Bucher ,
5 8
Werner Zimmerli , Beat Mueller* for the ProHOSP Study Group
Abstract
Introduction: Measurement of prohormones representing different pathophysiological pathways could enhance risk
stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI).
Methods: We assessed clinical parameters and five biomarkers, the precursor levels of adrenomedullin (ADM),
endothelin-1 (ET1), atrial-natriuretic peptide (ANP), anti-diuretic hormone (copeptin), and procalcitonin in patients with
LRTI and CAP enrolled in the multicenter ProHOSP study. We compared the prognostic accuracy of these biomarkers
with the pneumonia severity index (PSI) and CURB65 (Confusion, Urea, Respiratory rate, Blood pressure, Age 65) score
to predict serious complications defined as death, ICU admission
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