prolonged treatment with n-acetylcystine delays liver recovery from acetaminophen hepatotoxicity长期n-acetylcystine延误治疗肝脏康复对乙酰氨基酚肝毒性.pdfVIP

Available online /content/13/2/R55 Vol 13 No 2 Open Access Research Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity 1 1 2 1 1 Runkuan Yang , Keita Miki , Xin He , Meaghan E Killeen and Mitchell P Fink 1Department of Critical Care Medicine, University of Pittsburgh Medical School, 3550 Terrace Street, Pittsburgh, PA 15261, USA 2Department of Pathology, University of Pittsburgh Medical School, 3550 Terrace Street, Pittsburgh, PA 15261, USA Corresponding author: Runkuan Yang, Yangr@ Received: 3 Jan 2009 Revisions requested: 21 Feb 2009 Revisions received: 23 Mar 2009 Accepted: 9 Apr 2009 Published: 9 Apr 2009 Critical Care 2009, 13:R55 (doi:10.1186/cc7782) This article is online at: /content/13/2/R55 © 2009 Yang et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License /licenses/by/2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Acetaminophen (APAP) toxicity is the most hours of APAP challenge, the mice were given 100 mg/kg NAC common cause of acute liver failure in the US and Europe. dissolved in 0.6 mL saline, or saline treatment every 12 hours for Massive hepatocyte necrosis is the predominant feature of a total of 72 hours. APAP-induced acute liver injury (ALI). Liver regeneration is a vital process for survival after a toxic insult, it occurs at a relative late time point after the injurious phase. C