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psychological stress and fibromyalgia a review of the evidence suggesting a neuroendocrine link心理压力和纤维肌痛的审查证据表明神经内分泌链接.pdf

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psychological stress and fibromyalgia a review of the evidence suggesting a neuroendocrine link心理压力和纤维肌痛的审查证据表明神经内分泌链接

Arthritis Research Therapy Vol 6 No 3 Gupta and Silman Review Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link Anindya Gupta and Alan J Silman ARC Epidemiology Unit, School of Epidemiology and Health Sciences, Manchester, UK Corresponding author: Anindya Gupta (e-mail: anindya.gupta@man.ac.uk) Received: 23 Dec 2003 Revisions requested: 27 Jan 2004 Revisions received: 3 Mar 2004 Accepted: 18 Mar 2004 Published: 7 Apr 2004 Arthritis Res Ther 2004, 6:98-106 (DOI 10.1186/ar1176) © 2004 BioMed Central Ltd Abstract The present review attempts to reconcile the dichotomy that exists in the literature in relation to fibromyalgia, in that it is considered either a somatic response to psychological stress or a distinct organically based syndrome. Specifically, the hypothesis explored is that the link between chronic stress and the subsequent development of fibromyalgia can be explained by one or more abnormalities in neuroendocrine function. There are several such abnormalities recognised that both occur as a result of chronic stress and are observed in fibromyalgia. Whether such abnormalities have an aetiologic role remains uncertain but should be testable by well-designed prospective studies. Keywords: fibromyalgia, hormone, neurotransmitter, psychological stress Introduction The present review attempts to reconcile the conflict Fibromyalgia is the second most common diagnosis made