production of interleukin-1 receptor antagonist by human articular chondrocytes生产interleukin-1受体拮抗剂的人体关节软骨细胞.pdfVIP

Available online /content/4/3/226 Research article Production of interleukin-1 receptor antagonist by human articular chondrocytes 1 1 1 1 1,3 Gaby Palmer , Pierre-Andre Guerne , Francoise Mezin , Michel Maret , Jerome Guicheux , Mary B Goldring2 and Cem Gabay1 1Division of Rheumatology, University Hospital, Geneva, Switzerland 2New England Baptist Bone and Joint Institute and Rheumatology Division, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachussetts, USA 3Present address: INSERM EM 9903, School of Dental Surgery, Nantes, France Correspondence: Cem Gabay, MD, Division of Rheumatology, University Hospital, 26 avenue de Beau-Sejour, 1211 Geneva 14, Switzerland. Tel: +41 22 382 3501; fax: +41 22 382 3509; e-mail: Cem.Gabay@hcuge.ch Received: 25 October 2001 Arthritis Res 2002, 4:226-231 Revisions requested: 27 November 2001 This article may contain supplementary data which can only be found Revisions received: 20 February 2002 online at /content/4/3/226 Accepted: 11 March 2002 © 2002 Palmer et al., licensee BioMed Central Ltd Published: 8 April 2002 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one secreted (sIL-1Ra) and three intracellular (icIL-1Ra1, icIL-1Ra2 and icIL-1Ra3), derived from the same gene. We examined the produc