preresection obesity increases the risk of hepatobiliary complications in short bowel syndromepreresection肥胖肝胆管的并发症的风险增加短肠综合症.pdfVIP

Nutrients 2012, 4, 1358-1366; doi:10.3390/nu4101358 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Article Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome Jon S. Thompson 1,*, Rebecca A. Weseman 1, Fedja A. Rochling 1, Wendy J. Grant 1, 2 1 1 Jean F. Botha , Alan N. Langnas and David F. Mercer 1 The University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA; E-Mails: Rebecca.weseman@ (R.A.W.); frochling@ (F.A.R.); wgrant@ (W.J.G.); alangnas@ (A.N.L.); dmercer@ (D.F.M.) 2 University of the Witwatersrand, Johannesburg, 1 Jan Smuts Avenue, Braamfontein 2000, Johannesburg, South Africa; E-Mail: Jeanf.botha@ * Author to whom correspondence should be addressed; E-Mail: jthompso@ ; Tel.: + 1-402-559-7182; Fax: + 1-402-559-6749. Received: 28 June 2012; in revised form: 11 September 2012 / Accepted: 18 September 2012 / Published: 26 September 2012 Abstract: Patients developing the short bowel syndrome (SBS) are at risk for hepatobiliary disease, as are morbidly obese individuals. We hypothesized that morbidly obese SBS individuals would be at increased risk for developing hepatobiliary complications. We reviewed 79 patients with SBS, 53 patients with initial body mass index (BMI) 35 were controls. Twenty-six patients with initial BMI 35 were the obese group. Obese patients were more likely to be weaned off parenteral nutrition (PN) (58