predicting effects of blood flow rate and size of vessels in a vasculature on hyperthermia treatments using computer simulation预测影响血管的血流速度和规模的脉管系统使用计算机模拟在高热治疗.pdf

Huang et al. BioMedical Engineering OnLine 2010, 9:18 /content/9/1/18 RESEARCH Open Access Predicting effects of blood flow rate and size of vessels in a vasculature on hyperthermia treatments using computer simulation 1* 2 3 Huang-Wen Huang , Tzu-Ching Shih , Chihng-Tsung Liauh * Correspondence: hhw402@mail. Abstract .tw 1Department of Innovative Background: Pennes Bio Heat Transfer Equation (PBHTE) has been widely used to Information and Technology, Software Engineering Group, approximate the overall temperature distribution in tissue using a perfusion Langyang Campus, Tamkang parameter term in the equation during hyperthermia treatment. In the similar University, I-lan County 26247, modeling, effective thermal conductivity (Keff) model uses thermal conductivity as a Taiwan parameter to predict temperatures. However the equations do not describe the thermal contribution of blood vessels. A countercurrent vascular network model which represents a more fundamental approach to modeling temperatures in tissue than do the generally used approximate equations such as the Pennes BHTE or effective thermal conductivity equations was presented in 1996. This type of model is capable of calculating the blood temperature in vessels and describing a vasculature in the tissue regions. Methods: In this paper, a countercurrent blood vessel network (CBVN) model for calculating tissue tem