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Molecules 2012, 17, 13266-13274; doi:10.3390/molecules171113266 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Radioiodination of Aryl-Alkyl Cyclic Sulfates Chandra Mushti 1,* and Mikhail I. Papisov 2,* 1 Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Shriners Hospital for Children—Boston, Room 439, 51 Blossom St., Boston, MA 02114, USA 2 Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Shriners Hospital for Children—Boston, Room 224, 51 Blossom St., Boston, MA 02114, USA * Authors to whom correspondence should be addressed; E-Mails: cmushti@ (C.M.); papisov@ (M.I.P.); Tel.: +1-617-726-2000 (M.I.P). Received: 7 September 2012; in revised form: 24 September 2012 / Accepted: 23 October 2012 / Published: 7 November 2012 Abstract: Among the currently available positron emitters suitable for Positron Emission Tomography (PET), 124I has the longest physical half-life (4.2 days). The long half-life and well-investigated behavior of iodine in vivo makes 124I very attractive for pharmacological studies. In this communication, we describe a simple yet effective method for the synthesis of novel 124I labeled compounds intended for PET imaging of arylsulfatase activity in vivo. Arylsulfatases have important biological functions, and genetic deficiencies of such functions require pharmacological replacement, the efficacy of which must be properly and non-invasively evaluated. These enzymes, even though