原创力文档rapid pcr detection of group a streptococcus from flocked throat swabs a retrospective clinical study快速的a群链球菌pcr检测聚集喉部拭回顾性临床研究.pdfVIP
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rapid pcr detection of group a streptococcus from flocked throat swabs a retrospective clinical study快速的a群链球菌pcr检测聚集喉部拭回顾性临床研究
Slinger et al. Annals of Clinical Microbiology and Antimicrobials 2011, 10:33
/content/10/1/33
RESEARCH Open Access
Rapid PCR detection of group a streptococcus from
flocked throat swabs: A retrospective clinical study
1* 2 1 1 3 1
Robert Slinger , David Goldfarb , Derek Rajakumar , Ioana Moldovan , Nicholas Barrowman , Ronald Tam and
Francis Chan1
Abstract
Background: Rapid diagnosis of GAS pharyngitis may improve patient care by ensuring that patients with GAS
pharyngitis are treated quickly and also avoiding unnecessary use of antibiotics in those without GAS infection.
Very few molecular methods for detection of GAS in clinical throat swab specimens have been described.
Methods: We performed a study of a laboratory-developed internally-controlled rapid Group A streptococcus
(GAS) PCR assay using flocked swab throat specimens. We compared the GAS PCR assay to GAS culture results
using a collection of archived throat swab samples obtained during a study comparing the performance of
conventional and flocked throat swabs.
Results: The sensitivity of the GAS PCR assay as compared to the reference standard was 96.0% (95% CI 90.1% to
98.4%), specificity 98.6% (95% CI 95.8% to 99.5%), positive predictive value (PPV) 96.9% (95% CI 91.4% to 99.0%) and
negative predictive value (NPV) of 98.1% (95% CI 95.2% to 99.2%). For conventional swab cultures, sensitivity was
96.0% (95% CI 90.1% to 98.4%), specificity 100% (95% CI 98.2% to 100%), PPV 100%, (95% CI 96.1% to 100%) and
NPV 98.1% (95% CI 95.2% to 99.3%)
Conclusions: In this retrospective study, the GAS PCR assay appeared to perform as well as conventional throat
swab culture, the current standard of practice. Si
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