reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants活性氧诱导血管内皮生长因子的表达在软骨细胞和人类关节软骨移植组织.pdfVIP
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reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants活性氧诱导血管内皮生长因子的表达在软骨细胞和人类关节软骨移植组织
Available online /content/8/6/R189
Vol 8 No 6 Open Access
Research article
Reactive oxygen species induce expression of vascular
endothelial growth factor in chondrocytes and human articular
cartilage explants
1 2 2 2 3,4
Jakob Fay , Deike Varoga , Christoph J Wruck , Bodo Kurz , Mary B Goldring and
Thomas Pufe2
1Department of Trauma Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 7, 24105 Kiel, Germany
2Department of Anatomy, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
3Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, HIM-246, 4 Blackfan Circle,
Boston, MA 02115-5713, USA
4Hospital for Special Surgery, Caspary Research Building, Room 528, 535 E. 70th Street, New York, NY 10021, USA
Corresponding author: Thomas Pufe, t.pufe@anat.uni-kiel.de
Received: 13 Oct 2006 Revisions requested: 9 Nov 2006 Revisions received: 1 Dec 2006 Accepted: 23 Dec 2006 Published: 23 Dec 2006
Arthritis Research Therapy 2006, 8:R189 (doi:10.1186/ar2102)
This article is online at: /content/8/6/R189
© 2006 Fay et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Vascular endothelial growth factor (VEGF) promotes cartilage- PCR. Expression of VEGF and VEGF receptors (VEGFR-1 and
degrading pathways, and
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