reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants活性氧诱导血管内皮生长因子的表达在软骨细胞和人类关节软骨移植组织.pdfVIP

reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants活性氧诱导血管内皮生长因子的表达在软骨细胞和人类关节软骨移植组织.pdf

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reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants活性氧诱导血管内皮生长因子的表达在软骨细胞和人类关节软骨移植组织

Available online /content/8/6/R189 Vol 8 No 6 Open Access Research article Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants 1 2 2 2 3,4 Jakob Fay , Deike Varoga , Christoph J Wruck , Bodo Kurz , Mary B Goldring and Thomas Pufe2 1Department of Trauma Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 7, 24105 Kiel, Germany 2Department of Anatomy, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24098 Kiel, Germany 3Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, HIM-246, 4 Blackfan Circle, Boston, MA 02115-5713, USA 4Hospital for Special Surgery, Caspary Research Building, Room 528, 535 E. 70th Street, New York, NY 10021, USA Corresponding author: Thomas Pufe, t.pufe@anat.uni-kiel.de Received: 13 Oct 2006 Revisions requested: 9 Nov 2006 Revisions received: 1 Dec 2006 Accepted: 23 Dec 2006 Published: 23 Dec 2006 Arthritis Research Therapy 2006, 8:R189 (doi:10.1186/ar2102) This article is online at: /content/8/6/R189 © 2006 Fay et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Vascular endothelial growth factor (VEGF) promotes cartilage- PCR. Expression of VEGF and VEGF receptors (VEGFR-1 and degrading pathways, and

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