pulmonary hypertension associated with sarcoidosis肺动脉高压与结节病有关.pdfVIP

Available online /content/9/S2/S8 Review Pulmonary hypertension associated with sarcoidosis Robert P Baughman Department of Internal Medicine, Interstitial Lung Disease and Sarcoidosis Clinic, University of Cincinnati Medical Center, Holmes Eden Ave, Cincinnati, Ohio 45267, USA Corresponding author: Robert P Baughman, baughmrp@ Published: 15 August 2007 Arthritis Research Therapy 2007, 9(Suppl 2):S8 (doi:10.1186/ar2192) This article is online at /content/9/S2/S8 © 2007 BioMed Central Ltd Abstract tissues. Pulmonary involvement is common in sarcoid patients Pulmonary involvement is common in sarcoidosis, an immune- and may contribute to deteriorating lung function and the mediated inflammatory disorder that is characterized by non- eventual development of end-stage pulmonary fibrosis [2]. caseating granulomas in tissue. Sarcoid patients with advanced pulmonary disease, especially end-stage pulmonary fibrosis, risk The chest roentgenogram of patients with sarcoidosis includes developing pulmonary hypertension (World Health Organization those with interstitial lung disease with adenopathy (stage II), group III pulmonary hypertension secondary to hypoxic lung disease). interstitial lung disease (stage III), or fibrosis (stage IV). Increased levels of endothelin (ET)-1 in plasma and broncho- alveolar lavage of some sarcoid patients suggest that ET-1 may be Patients with advanced pulmonary disease, with vital driving pulmonary fibrosis and sarcoidosis-associated pulmonary capacities of less than 60% p