prognostic consequences of borderline dysnatremia pay attention to minimal serum sodium change预后的后果边缘型dysnatremia注意血清钠变化最小.pdfVIP

Darmon et al. Critical Care 2013, 17:R12 /content/17/1/R12 RESEARCH Open Access Prognostic consequences of borderline dysnatremia: pay attention to minimal serum sodium change 1* 1 2 3,4 5 6 Michael Darmon , Eric Diconne , Bertrand Souweine , Stéphane Ruckly , Christophe Adrie , Elie Azoulay , 7 8 4 9 10 Christophe Clec’h , Maïté Garrouste-Orgeas , Carole Schwebel , Dany Goldgran-Toledano , Hatem Khallel , Anne-Sylvie Dumenil11, Samir Jamali12, Christine Cheval13, Bernard Allaouchiche14, Fabrice Zeni1 and Jean-François Timsit3,4 Abstract Introduction: To assess the prevalence of dysnatremia, including borderline changes in serum sodium concentration, and to estimate the impact of these dysnatremia on mortality after adjustment for confounders. Methods: Observational study on a prospective database fed by 13 intensive care units (ICUs). Unselected patients with ICU stay longer than 48 h were enrolled over a 14-year period were included in this study. Mild to severe hyponatremia were defined as serum sodium concentration 135, 130, and 125 mmol/L respectively. Mild to severe hypernatremia were defined as serum sodium concentration 145, 150, and 155 mmol/L respectively. Borderline hyponatremia and hypernatremia were defined as serum sodium concentration between 135 and 137 mmol/L or 143 and 145 respectively. Results: A total of 11,125 patients were included in this study. Among these patients, 3,047 (27.4%) had mild to severe hyponatremia at ICU admission, 2,258 (20.3%) had borderline hyponatremia at ICU admission, 1,078 (9