原创力文档prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in uganda患病率和轮状病毒感染的相关因素在乌干达儿童急性腹泻承认.pdfVIP
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prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in uganda患病率和轮状病毒感染的相关因素在乌干达儿童急性腹泻承认
Nakawesi et al. BMC Pediatrics 2010, 10:69
/1471-2431/10/69
RESEARCH ARTICLE Open Access
Prevalence and factors associated with rotavirus
infection among children admitted with acute
diarrhea in Uganda
1* 2 1 2 1
Jane S Nakawesi , Eric Wobudeya , Grace Ndeezi , Edison A Mworozi , James K Tumwine
Abstract
Background: Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide.
Children in developing countries die more because of several factors including poorer access to hydration therapy
and greater prevalence of malnutrition. Hitherto, the magnitude of rotavirus disease in Uganda has remained
unknown. This study was therefore done to determine the prevalence and factors associated with rotavirus
infection among children aged 3-59 months admitted with acute diarrhea to paediatric emergency ward of
Mulago Hospital, Uganda
Methods: Three hundred and ninety children, aged between 3-59 months with acute diarrhoea were recruited.
The clinical history, socio-demographic characteristics, physical examination findings and laboratory investigations
were recorded. Stool samples were tested for rotavirus antigens using the DAKO IDEIA rotavirus EIA detection kit.
Results: The prevalence of rotavirus infection was 45.4%. On multivariate analysis rotavirus was significantly
associated with a higher education (above secondary) level of the mother [OR 1.8; 95% CI 1.1-2.7]; dehydration [OR
1.8; 95% CI 1.1-3.0] and breastfeeding [OR 2.6; 95% CI 1.4-4.0]. Although age was significantly associated with
rotavirus on bivariate analysis; this association disappeared on multivariate analysis. No significant association was
found between rotavirus infection and nutritional status, HIV status and attend
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