prognostic significance of functional somatic symptoms in adolescence a 15-year community-based follow-up study of adolescents with depression compared with healthy peers预后意义的功能性躯体症状在青春期15年以社区为基础的后续研究与抑郁症的青少年与健康同行.pdfVIP

Bohman et al. BMC Psychiatry 2012, 12:90 /1471-244X/12/90 RESEARCH ARTICLE Open Access Prognostic significance of functional somatic symptoms in adolescence: a 15-year community- based follow-up study of adolescents with depression compared with healthy peers 1* 1,2 1 2 1 1 Hannes Bohman , Ulf Jonsson , Aivar Päären , Lars von Knorring , Gunilla Olsson and Anne-Liis von Knorring Abstract Background: There is a lack of population-based long-term longitudinal research on mental health status and functional physical/somatic symptoms. Little is known about the long-term mental health outcomes associated with somatic symptoms or the temporal relationship between depression and such symptoms. This 15-year study followed up adolescents with depression and matched controls, screened from a population-based sample, who reported different numbers of somatic symptoms. Methods: The total population of 16– 17-year-olds in Uppsala, Sweden, was screened for depression in 1991– 1993. Adolescents who screened positive and an equal number of healthy controls took part in a semi-structured diagnostic interview. In addition, 21 different self-rated somatic symptoms were assessed. Sixty-four percent of those adolescents participated in a follow-up structured interview 15 years later. Results: Somatic symptoms in adolescence predicted depression and other adult mental disorders regardless of the presence of adolescent depression. In adolescents with depression, the number of functional somatic symptoms predicted, in a dose response relationship, suicidal behavior, bipolar episodes, and psychotic episodes as well as chronic and recurrent depression. Contrary to expectations, the somatic symptoms o