prognostic significance of mir-194 in endometrial cancermir - 194在子宫内膜癌的预后意义.pdfVIP

Zhai et al. Biomarker Research 2013, 1:12 /content/1/1/12 RESEARCH Open Access Prognostic significance of miR-194 in endometrial cancer 1 1 2 2 1* Haiyan Zhai , Mihriban Karaayvaz , Peixin Dong , Noriaki Sakuragi and Jingfang Ju Abstract Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical significance of miR-194 was investigated in archival EC specimens. We extracted total RNA from thirty-two EC samples and quantified the expression level of miR-194. We discovered that the expression level of miR-194 was significantly (P = 0.03) lower in type I EC patients with more advanced stage. In addition, patients with higher miR-194 levels have better prognosis than those with lower miR-194 levels (P = 0.0067; Cut-off value of miR-194 = 0.3). These results indicate that miR-194 has potential to serve as prognostic biomarker for EC patients. Keywords: MiR-194, Endometrial cancer Background pathological diagnosis based on the morphological Endometrial cancer (EC) is the most frequent malignant alterations, to better predict the outcome of EC. tumor occurring in the female genital tract in the United In the past 10 years, small regulatory RNAs have gained States [1]. Generally EC cases can be classified into two enormous interests i