原创力文档prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin壶腹癌的预后基于免疫组织化学类型和骨桥蛋白的表达.pdfVIP
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prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin壶腹癌的预后基于免疫组织化学类型和骨桥蛋白的表达
Zhao et al. Diagnostic Pathology 2011, 6:98
/content/6/1/98
RESEARCH Open Access
Prognosis of ampullary cancer based on
immunohistochemical type and expression
of osteopontin
*
Xiang-qian Zhao, Jia-hong Dong , Wen-zhi Zhang and Zhe Liu
Abstract
Background: Ampullary cancer (AC) was classified as pancreatobiliary, intestinal, or other subtype based on the
expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20). We aimed to explore the association of AC subtype
with patient prognosis.
Methods: The relationship of AC subtype and expression of Osteopontin (OPN) with the prognosis of 120 AC
patients after pancreaticoduodenectomy was investigated.
Results: The patients had pancreatobiliary (CK7+ - - +
/CK20 , n = 24, 20%), intestinal (CK7 /CK20 , n = 29, 24.2%) or
+ + - -
other (CK7 /CK20 or CK7 /CK20 , n = 67, 55.8%) subtypes of AC, and their median survival times were 23 ± 4.2, 38
± 2.8 and 64 ± 16.8 months, respectively. The survival times of 64 OPN- patients (53.3%) and 56 OPN+ patients
(46.7%) were 69 ± 18.4 and 36 ± 1.3 months, respectively. There was no significant effect of AC subtype on survival
of OPN- patients. For OPN+ patients, those with pancreatobiliary AC had a shorter survival time (22 ± 6.6 months)
than those with intestinal AC (37 ± 1.4 months, p = 0.041), and other AC subtype (36 ± 0.9 months, p = 0.010);
intestinal and other AC subtypes had similar survival times.
Conclusions: The prognosis of AC patients can be estimated based on immunohistochemical classification and
OPN status.
Keywords: ampullary cancer, osteopontin, survival analysis, immunohistochemistry, classific
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