programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients程序性死亡1水平与死亡率增加,脓毒性休克患者的院内感染和免疫功能紊乱.pdfVIP

下载本文档

1
0
约8.8万字
约 11页
2017-09-11 发布于上海
举报
版权申诉

programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients程序性死亡1水平与死亡率增加,脓毒性休克患者的院内感染和免疫功能紊乱.pdf

1、本文档共11页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients程序性死亡1水平与死亡率增加,脓毒性休克患者的院内感染和免疫功能紊乱

Guignant et al. Critical Care 2011, 15:R99 /content/15/2/R99 RESEARCH Open Access Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients 1 2 3 1 4 1 Caroline Guignant , Alain Lepape , Xin Huang , Hakim Kherouf , Laure Denis , Françoise Poitevin , 1 5 5 6 3 Christophe Malcus , Aurélie Chéron , Bernard Allaouchiche , François Gueyffier , Alfred Ayala , Guillaume Monneret1*† and Fabienne Venet1† Abstract Introduction: Septic shock remains a major health care problem worldwide. Sepsis-induced immune alterations are thought to play a major role in patients’ mortality and susceptibility to nosocomial infections. Programmed death-1 (PD-1) receptor system constitutes a newly described immunoregulatory pathway that negatively controls immune responses. It has recently been shown that PD-1 knock-out mice exhibited a lower mortality in response to experimental sepsis. The objective of the present study was to investigate PD-1-related molecule expressions in septic shock patients. Methods: This prospective and observational study included 64 septic shock patients, 13 trauma patients and 49 healthy individuals. PD-1-related-molecule expressions were measured by flow cytometry on circulating leukocytes. Plasmatic interleukin (IL)-10 concentration as well as ex vivo mitogen-induced lymphocyte proliferation were assessed. Results: We observed that septic shock patients displayed increased PD-1, PD-Ligand1 (PD-L1) and PD-L2 monocyte expressions and enhanced PD-1 and PD-L1 CD4+ T lymphocyte expressions at day 1-2 and 3-5 after the onse