原创力文档prevalence and risk factors of vertebral compression fractures in female sle patients椎体压缩骨折发病率和危险因素的女性系统性红斑狼疮患者.pdfVIP
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prevalence and risk factors of vertebral compression fractures in female sle patients椎体压缩骨折发病率和危险因素的女性系统性红斑狼疮患者
Almehed et al. Arthritis Research Therapy 2010, 12:R153
/content/12/4/R153
RESEARCH ARTICLE Open Access
Prevalence and risk factors of vertebral
compression fractures in female SLE patients
1* 2,3 4 1 1
Katarina Almehed , Szabolcs Hetényi , Claes Ohlsson , Hans Carlsten , Helena Forsblad-d’Elia
Abstract
Introduction: Our objective was to determine the frequency of and factors associated with prevalent vertebral
compression fractures in female systemic lupus erythematosus (SLE) patients attending rheumatologists in western
Sweden.
Methods: In this cross sectional study 150 women were included. They were examined with x-ray of thoracic and
lumbar spine (Th4 to L4). A reduction of at least 20% of any vertebral height, assessed by Genant’s
semiquantitative method, was defined as a fracture. Bone mineral density (BMD) was measured by dual energy
x-ray absorptiometry (DXA).
Results: Median patient age was 47 years (20 to 82) and disease duration 11 years (1 to 41). Only 6 (4%) women
had a history of clinical compressions whereas 43 (29%) had at least one radiological fracture each. The patients
with at least one fracture at any site were characterized by older age (P 0.001), being postmenopausal (P 0.01),
higher Systemic Lupus International Collaborative Clinics Damage Index (P 0.05), lower BMD total hip and
femoral neck (P 0.05), more peripheral fractures (P 0.01), medication with bisphosphonates (P 0.05) and
calcium and vitamin D3 (P 0.05). There were no significant differences regarding current or cumulative
glucocorticosteroid dose between the groups. In logistic regression analyses high age remained as a risk factor of
at least one vertebral fracture at any site whereas low BMD in to
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