progress in spondylarthritis. progress in studies of the genetics of ankylosing spondylitis脊椎关节炎的进展。.pdfVIP

Available online /content/11/5/254 Review Progress in spondylarthritis Progress in studies of the genetics of ankylosing spondylitis Matthew A Brown Diamantina Institute of Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane 4102, Australia Corresponding author: Matthew A Brown, matt.brown@.au Published: 29 October 2009 Arthritis Research Therapy 2009, 11:254 (doi:10.1186/ar2692) This article is online at /content/11/5/254 © 2009 BioMed Central Ltd Abstract the disease 5.6 to 16 times greater than B27-positive The advent of high-throughput SNP genotyping methods has individuals in the general population, implying the presence of advanced research into the genetics of common complex genetic non-B27 shared familial risk factors [5,6]. A major non-B27 diseases such as ankylosing spondylitis (AS) rapidly in recent contribution to susceptibility to AS is suggested by the times. The identification of associations with the genes IL23R and greater concordance rate of monozygotic twins (63%) than of ERAP1 have been robustly replicated, and advances have been B27-positive dizygotic twin pairs (23%) [7]. made in studies of the major histocompatibility complex genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of the Recurrence risk modeling indicates that the observed pattern immunological pathways involved in AS, and raising novel potential of disease recurrence in families best fits